The topic will be the structure-function relationship in enzymes, in the specific case of [FeFe]-hydrogenase. Protein will be purified and crystallised which will then be photochemically activated and subsequently characterised spectroscopically and via (time-resolved) X-ray crystallography. Further details on the PhD programme can be found under this link.

Tous les doctorants ayant soutenu ou soutenant leur thèse entre le 1er janvier 2022 et le 31 décembre 2023 peuvent être candidats au prix de thèse du groupement d’intérêt scientifique. Conditions d’attribution du prix de thèse: les travaux de thèse doivent avoir été réalisés au sein d’une équipe appartenant au GIS FrenchBIC (liste des équipes membres consultables ici).

The objectives of the project are to develop new lanthano-peptides catalysts with a well-folded peptide scaffold, high affinity for Ln(III) and positive interactions for substrate binding. The project will include peptide design and synthesis, characterisations using advanved analytical techniques (paramagnetic NMR, time-resolved luminescence) and molecular modelling, as well as evaluation of Ln-peptide catalysts on model reactions. Web: https://hureaulab.wixsite.com/equipeflcc

The project’s aim is to elaborate a luminescent Cu(II)-sensor, that is able to measure specifically labile/exchangeable Cu(II)-concentrations in biological systems, from simpler cell culture medium to the challenging blood plasma. Such a Cu(II)-sensor would be very useful as a tool to understand the Cu metabolism and might have applications for diagnosis of diseases with increased exchangeable Cu pool concentrations such as Wilson’s or Alzheimer’s disease. The project incolves a consortium with several collaborators from different disciplines, including group from the …

[Expired] Postdoc Position (2 years) in Bio/Medicinal Inorganic Chemistry in Strasbourg on “Luminescent Sensor to Detect the Labile Cu(II)-Pool, a Diagnostic Parameter for Wilson’s and Alzheimer’s diseasethe project” Read more »

Rébecca Leblay, from the group BiosCiences, iSm2, Marseille spent two weeks in the LCC in Toulouse. This project was supported by FrenchBIC. My PhD aims at studying the activity of LPMO (Lytic Polysaccharide MonoOxygenases) bioinspired synthetic complexes and their potential activity to valorize recalcitrant biomass. Besides, in Toulouse, peptide ligands with a structure inspired of the first coordination sphere of the LPMO active site have been synthetized. To compare the nature and mechanism of oxidation by synthetic/peptide complexes, enzymes and …

[Project supported by FrenchBIC] Études mécanistiques de complexes à cuivre bioinspirés par la LPMO Read more »