Category: Expired

Luminescent lanthanide complexes for live cell microscopy. We are looking an organic / peptide chemist to design luminescent probes for live cell microscopy imaging at the Laboratory of Chemistry and Biology of Metals.

Laboratory of Chemistry and Biology of Metals (LCBM), Grenoble. Computational chemistry, Modellig, and X-rays (CoMX) team.

Fluorescent probes for the detection and quantification of traces of copper(II) in biological fluids. The projects aims at designing peptide and lanthanide-based sensors to detect Cu(II) by fluorescence in biological fluids. We are looking for a motivated postdoc with skills in molecular chemistry.

The  objective of this project is to develop novel bioinspired nanohybrid catalysts based on synthetic copper complexes fo ORR and OER. These complexes will be immobolized at Carbon-Nanotubes-based electrodes. The position is avalable as soon as possible

A postdoctoral position in Structural Biology is available in the Metalloproteins group at IBS in Grenoble, France.

Financing: Labex Arcane (https://arcane.univ-grenoble-alpes.fr) Place of work: CEA/LCBM, Grenoble, France (https://www.cbm-lab.fr/en) Directors of thesis: Dr. Ragnar Bjornsson (CEA Grenoble), Dr. Christine Cavazza (CEA Grenoble) PhD starting date: October 2024

Interested in biological imaging with metal complexes? We are looking for a PhD in organic/bioorganic/inorganic chemistry to develop luminescent probes for cell and small animal imaging.

The project, developed within two laboratories in Grenoble (DCM and LCBM), aims to develop efficient and selective catalysts for electro driven hydrogenation reactions of unsaturated C-O/C-N bonds using metal-pincer complexes and the integration of the latter into functional photo(electro)catalytic systems.

We are looking for a research assistant (AI) for managing the chemistry labs of two research teams (CIRE and EMPRE, see the link) and the synthesis of organic molecules and coordination complexes. One year initial contract with possible extension.

to study the reactivity of metal-thiolate complexes towards molecular nitrogen and other N-containing small molecules

Synthesis of biomimetic copper complexes to understand the role of Met-rich domains in copper homeostasis.

ouvert à concours dans le laboratoire de Physiologie Cellulaire & Végétale à Grenoble (France) pour étudier la tolérance aux métaux chez les plantes. https://jobs.inrae.fr/concours/concours-charges-recherche-classe-normale-profil-h-f/cr-2022-bap-5

Carbazole-based luminescent lanthanide bioprobes for reactive oxygen species sensing in live cells

Le laboratoire de Chimie et Biologie des Métaux (LCBM UMR5249 CNRS/CEA/UGA) est à la recherche d’une chercheuse/chercheur post-doctoral.es pour un projet à l’interface Chimie/Biologie; en partenariat avec la start-up INNOVERDA dans le cadre du plan de relance.

Research in the Laboratory of Chemistry and Biology of Metals (CBM, Grenoble, France. https://www.cbm-lab.fr/en) focuses on the study of the structure, activity and regulation of complex biological systems that transport and use metal ions, and on the development of bio-inspired systems for applications in health, the environment and energy. The size of the Laboratory and the coherence of its research make it unique at both the national and international levels.

The pluri-disciplinary project, developed by a collaboration between two teams of the Lab BEE and BioCE, deals with in cristallo biocatalysis for a sustainable chemistry is still open. Our strategy for catalysis consists in the use of crystals of metalloenzymes to perform cascade reactions, that will impact the organic synthesis and the mode of drug synthesis.

The pluri-disciplinary project, developed by a collaboration between two teams of the Lab BEE and BioCE, deals with in cristallo biocatalysis for a sustainable chemistry. Our strategy for catalysis consists in the use of crystals of metalloenzymes to perform cascade reactions.

At the Laboratory of Chemistry and Biology of Metals, CEA Grenoble. The goal is to implement bio-orthogonal chemistry in mammalian cells and apply it for the study of the copper chaperone Atox1 by different approaches such as super resolution fluorescence microscopy.

Theoretical studies of Copper Centers to understand the reactivity of novel copper based catalysts capable of effectively oxidizing strong C-H bonds under mild and ecocompatible conditions and  to study one of the key steps of the biosynthesis of melanins by tyrosinase, a binuclear copper enzyme.

Permanent contract with CEA at Grenoble – IRIG, SyMMES (UMR 5819 Univ. Grenoble Alpes, CEA, CNRS)

Department of Molecular Chemistry offers a full-time PhD Position (m/f) for a period of 3 years, starting in October 2020.

A doctoral position is available in the Metalloproteins Unit (MU) at the Institut de Biologie Structurale (IBS) in Grenoble – France to work on the structural study of the assembly machinery of the nitrogenase active site.

A background in molecular biology and protein biochemistry is essential, knowledge of macromolecular crystallography would be an advantage. Details and application at: https://esrf.gestmax.eu/1397/1/phd-position-structural-basis-of-melanogenesis-enzymes/en_US

Investigation of the peculiar nickel-binding site of the metalloprotein CooT by hyperpolarized solid-state NMR

Implementation of noble metal-free catalytic nanomaterials in water splitting electrolyzers

Laboratory of chemistry and Biology of Metals (LCBM, Grenoble) Team : BioCE, Head : Dr S. Ménage Internaship supervisor : S. Ménage (DR CNRS) or C. Marchi-Delapierre (MCF HDR) (caroline.marchi-Delapierre@cea.fr)

Beginning September-October 2019

KeyWords: Artificial metalloenzyme – heterogeneous catalysis

KeyWords: artificial metalloenzyme – G quadruplex – catalysis

Protein‐Based Nanotechnologies for the development of biosensors and bio‐batteries

Place of work: BIG, CEA-Grenoble, Rhône-Alpes, France Salary: ~2000-2200 € / month

Development of ultrastable fluorescent proteins markers for quantitative super resolution microscopy at cryogenic temperature.