[Expired] 6 months M2 training at the Centre de Biophysique Moléculaire in Orléans : Synthesis and characterization of lanthanide-based metallacrowns for near-infrared biological imaging
The project aims to take advantage of the near-infrared (NIR) emission of lanthanide ions (LnIII) in an innovative multiplex imaging approach to establish an accurate map of SKCa channel subtypes and to correlate it with a disease prognosis and/or to optimize treatments. To achieve this goal, a series of imaging probes based on lanthanide(III)/gallium(III) metallacrowns exhibiting fingerprint bright emission in the NIR range and conjugated to peptides with controlled specificity for the SKCa family will be prepared.