[Expired] Post doctoral position available in Marseille: electrochemistry and mechanistic studies of hydrogenase enzymes
Our group investigates the function and maturation of various metalloenzymes: molybdenum enzymes, hydrogenases and CO-dehydrogenases. We are interested in all steps in the catalytic mechanism of these enzymes: long distance electron transfer, active site chemistry, reaction with inhibitors such as O2. We seek to understand the molecular basis of some of the global properties of redox enzymes, including catalytic bias, substrate specificity and resistance to chemical stress. We have also developed new methodologies that make it possible to use electrochemistry for studying certain steps in the catalytic mechanism that may be difficult to probe using conventional techniques (such as mass transport along substrate channels). More information about our work can be found on our web site: http://www.bip06.fr
The post-doct will use direct electrochemistry and other kinetic methods to study various aspects of the reactivity of FeFe and NiFe hydrogenases. These enzymes oxidize and produce H2 and are studied in various contexts ranging from fundamental catalysis to the design of biofuel cells. Here we will focus on the molecular aspects of catalysis, using an interdisciplinary collaboration with biochemists/molecular biologists, spectroscopists and theoretical chemists.
The candidates will have a background in physical chemistry. He/she will be interested in the pluridisciplinary approach that we develop.