The fifth FrenchBIC online webinar will take place on Friday April 8th at 10.30am, and it will be given by: Wadih Ghattas (ICMMO, Orsay), Artificial metalloenzymes as catalysts, future drugs, and tools for fundamental science (abstract); Ievgen Mazurenko (BIP, Marseille), Met-rich Domains and Cu+ Oxidation by Multicopper Oxidases: an Electrochemical Study (abstract). The format of the seminar is two 30+10 min talks, followed by a meeting time in an online space for informal discussions. The seminar will be given online, …

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Recruté en 2016 à l’Institut de Chimie Moléculaire et des Matériaux d’Orsay (UMR 8182), Wadih Ghattas travaille à la conception, la construction, la caractérisation et l’étude de l’activité catalytique de la première métalloenzyme artificielle in vivo, un domaine de recherche où des protéines sont détournées de leur fonction primaire pour en faire des catalyseurs de réaction abiologiques.

The project involves structure determination of novel metalloenzymes by X-ray crystallography, with a focus on enzymes catalyzing peptides (RiPPs) post-translational modifications. Our goal is to decipher the mechanism and mode of interactions between these enzymes and their substrate.

A post-doctoral position in structural biology is available at the ChemSyBio team (Paris-Saclay University, INRAE, Micalis) headed by Dr Olivier Berteau. The project involves structure determination of novel metalloenzymes catalyzing post-translational modifications in peptides (ribosomally synthesized and post-translationally modified peptides, RiPPs) in order to decipher their mechanisms and enzyme substrate interactions.