[Job] Two funded Ph.D positions are opened in Marseille in the field of copper metalloenzyme and bioinspired models (starting Autumn 2025)
The projects are centered on the study of a copper containing metalloenzyme involved in recalcitrant biomass valorization.
Lytic Polysaccharide Monooxygenases (LPMO) have emerged as a class of enzyme of high interest for improved depolymerization of recalcitrant polysaccharides from biomass. LPMO are copper-containing enzymes which catalyze the hydroxylation of a strong C-H bond at the glycosidic linkage of the polysaccharide further leading to chain cleavage. The active site contains a mononuclear copper ion ligated by two histidines in an unusual “histidine-brace” motif.
- The first project (PEPR-funded, PuLCO; ANR-24-PEBB-0009) is centered on structure-function relationships studies of the enzymatic system (more information and application here: https://emploi.cnrs.fr/Offres/Doctorant/UMR7313-ARISIM-006/Default.aspx?lang=EN)
- The second projet (ANR LPMO-PEPS ANR-24-CE07-6490) aims at designing bioinspired functional copper-containing models by go-back-and-forth investigations between the enzymatic system and metallopeptides (more information and application here: https://emploi.cnrs.fr/Offres/Doctorant/UMR7313-ARISIM-007/Default.aspx?lang=EN )
Highly motivated candidates (master degree or equivalent with excellent academic records) with a background in chemistry and / or biochemistry and / or biophysics are strongly encouraged to apply. Previous laboratory experience in coordination chemistry, protein chemistry, metalloenzyme or any other field that could benefit the project would be valuable but is not mandatory.
Applications have to be submitted on the CNRS portal
Expires on Thursday May 15th, 2025