The aim of this project, emerged within the L2CM laboratory, is to develop a novel approach utilizing optical imaging to track the biotransformations of metal-based drug candidates in view of rationalizing their further pharmacomodulation. This will allow to establish a relationship between metal’s coordination sphere, metal-ligand interaction, and the complexes’ biotransformations to rationalize drug design. Web: http://www.l2cm.univ-lorraine.fr/l2cm/