[Expired] Post-doc offer: electrochemical studies of CO dehydrogenases

In our group at the BIP (http://bip.cnrs-mrs.fr/bip06/), we use direct electrochemistry as en enzyme kinetics method to study the reactivity of metalloenzymes. Among them, we study the the CO dehydrogenase (CODH), which catalyze the reversible reduction of CO₂ to CO: CO₂ + 2e^– + 2H⁺ ⇔ CO + H₂O. Our group is in a unique position for studying this enzyme, since we have access to a number of different CODHs from different organisms, some through collaborations, and some internal to the group. We also can construct variants using site-directed mutagenesis. Preliminary work has already uncovered very significant differences between these enzymes, in spite of a very conserved amino acid sequence.

We recently got funding from the French ANR for a post-doctoral position to understand the molecular origins of the properties of these enzymes.

The candidate will have a background in physical chemistry or biochemistry. They will speak english and will be interested in the pluridisciplinary approach that we develop.

To apply, please send a resume to

Suggested readings:

• M. Merrouch, J. Hadj-Saïd, L. Domnik, H. Dobbek, C. Léger, S. Dementin, and V. Fourmond. Chem. Eur. J., 21 (52), 18934–18938, Nov. 2015. doi: 10.1002/chem.201502835.
• L. Domnik, M. Merrouch, S. Goetzl, J.-H. Jeoung, C. Léger, S. Dementin, V. Fourmond, and H. Dobbek. Angew. Chem. Int. Ed. Engl., 56 (48), 15466–15469, Nov. 2017. doi: 10.1002/anie.201709261