[Job] Job Offer: Permanent staff scientist position on Structure-function relationships of metalloproteins

A permanent staff scientist position is available in the Metalloproteins Unit (MU) at the Institut de Biologie Structurale (IBS) in Grenoble – France (https://www.ibs.fr/research/research-groups/metalloproteins-group/) to work on the structure-function relationships of metalloproteins sensitive to oxygen with a particular focus on radical S-adenosyl-L-methionine (SAM) proteins. These enzymes use the reduction of a [Fe4S4] cluster to homolytically cleave SAM, producing a highly reactive 5’-deoxyadenosyl radical species, which will, in turn, trigger various radical-based reactions on a broad range of substrates. In the metalloproteins unit, we are interested in the structural study of several members of this vast superfamily of proteins involved in the tailoring of ribosomally-synthesized and post-translationally modified peptides.

The successful candidate will endeavor to develop his/her project around already existing and new collaborations. He/she will gradually participate in grant applications within the group and will benefit from the technical support and the expertise of its members. The MU combines structural and theoretical approaches to decipher the catalytic mechanism of metalloproteins sensitive to oxygen. For the last twenty-two years, the MU has developed a unique set of gloveboxes to work “from gene to structure” under anaerobic conditions, including a crystallization robot to perform automated high-throughput crystallization screenings.

The candidate should hold a PhD degree in structural biology and some previous post-doctoral experience. He/she should have a confirmed experience in protein expression and purification as well as crystallization. A strong background in chemistry and enzyme mechanisms would be an advantage. He/she should have previous wet-lab experimental experience as well as an interest for further experimental developments. A good knowledge of state-of-the-art crystallography software is also expected. The candidate should ideally be familiar with the French research system and be autonomous at work.

We are looking for a highly enthusiastic and open-minded researcher with good communication skills who likes to work in a multidisciplinary team and who is willing to train students.

To apply, please provide a detailed resume, a summary of your past research activity, a letter to describe how you would fit to the requested profile and two reference letters to Yvain Nicolet, head of the Metalloproteins group. You can contact him for further information ( (+33 4 57 42 86 03)). Application deadline May 31st 2020

Web: https://www.ibs.fr/research/research-groups/metalloproteins-group/

Annonce-Permanent-staff-scientist

Expires on Sunday May 31st, 2020

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